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Mathematical Models for the
Adhesion of Lipid Membranes

Riccardo Rosso         & - Epifanio G. Virga

Abstract:

We briefly report on some results concerning the adhesion of lipid membranes on rigid walls. After a short Introduction, in Section 2 we study a unilateral equilibrium problem for the energy functional of lipid tubules subject to an external field. These tubules may form assemblies when they are brought in contact, and so made to adhere to one another along flat interstices. The contact energy is taken to be proportional to the area of contact through a constant, which is called the adhesion potential. This competes against the external field in determining the stability of patterns with flat interstices. Though the equilibrium problem is highly nonlinear, we determine explicitly the stability diagram for the adhesion between tubules. We conclude that the higher the field, the lower the adhesion potential needed to make flat interstices energetically favourable, though its critical value depends also on the surface tension of the interface between tubules and the isotropic fluid around them. Focusing our attention on thin tubules, in Section 3 we are concerned with the effects of the geometry of an adhesive wall on the equilibrium condition that holds at the detachment points, where tubules and wall loose contact. As a result, this condition depends on the curvature of the wall, which thus plays a central rôle in determining whether the adhesion of a tubule is possible. This rôle is clearly illustrated by a comparison between two equilibrium problems, where a tubule adhere either to a flat or to a curved wall.

In Section 4, we obtain a covariant equation that determines the equilibrium shape of a free lipid membrane, when a general free-energy functional is employed to describe its elasticity. Moreover, we study the equilibrium of an open membrane free to adhere to a rigid wall. The characteristic feature of an open membrane is that it exhibits a border, which could also be adhesive. Our main objective is to arrive at the equilibrium conditions to be imposed on an adhesive border. In particular, these conditions are applied to a simple problem, which models the adhesion of a membrane to an axisymmetric profile. For this example we are also able lo study the stability of the adhesive border.



 
next up previous
Next: Introduction
Andre Sonnet
1999-06-28